Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 253: Issue 2
Radioiodination of monoclonal antibody for prostate specific antigen
Authors:
K. Bapat Bhabha Atomic Research Centre Radiopharmaceuticals Division Mumbai 400 085 India

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A. Korde Bhabha Atomic Research Centre Radiopharmaceuticals Division Mumbai 400 085 India

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M. Zaidi Tunisia

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A. Mukherjee Bhabha Atomic Research Centre Radiopharmaceuticals Division Mumbai 400 085 India

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M. Pillai Bhabha Atomic Research Centre Radiopharmaceuticals Division Mumbai 400 085 India

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M. Venkatesh Bhabha Atomic Research Centre Radiopharmaceuticals Division Mumbai 400 085 India

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Pages:
227–230
Online Publication Date:
01 Nov 2004
Publication Date:
17 Aug 2002
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1019689423516
Restricted access

Abstract  

Prostate specific antigen (PSA) is a reliable biochemical marker used in screening for prostate carcinoma. Immunoradiometric assays (IRMA) are generally used for the estimation of total/free PSA in serum samples. Radiolabeled antibody, an important reagent of IRMA was prepared and characterized using an in-house anti-PSA monoclonal antibody (Mab), Mab-2S. Mab-2S was radiolabeled with 125I and characterized for immunoreactivity and radiochemical purity. The usability of the radioiodinated Mab as tracer in IRMA was ascertained using authentic reagents for IRMA of PSA.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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