The preparation of dopaminergic agonist [5,8-3H] (+/-) 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

D. Orphanos; C. Filer

doi:10.1023/a:1020838925044

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 254: Issue 1

The preparation of dopaminergic agonist [5,8-3H] (+/-) 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene at high specific activity

Authors:

D. Orphanos

D. Orphanos Perkin Elmer Life Science, Inc 549 Albany St. Boston Massachusetts 02118 USA

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and

C. Filer

C. Filer Perkin Elmer Life Science, Inc 549 Albany St. Boston Massachusetts 02118 USA

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Pages:: 223–224

Online Publication Date:: 22 Dec 2004

Publication Date:: 17 Oct 2002

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1020838925044

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Abstract

The rigid dopamine analogue (+/-) 6,7-ADTN was originally synthesized to probe the geometrical constraints of the dopamine receptor family and [³H] (+/-) 6,7-ADTN was required for receptor binding assay. The radioligands was prepared by means of catalytic tritium dehalogenation of a suitable dibromo precursor and characterized by HPLC and tritium NMR. It has proven very useful as a tool to study dopaminergic receptors.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)