Synthesis and biodistribution of 99mTcN(CHIPDTC)2 as a potential myocardial perfusion imaging agent

JunBo Zhang; XueBin Wang; ChunYun Li

doi:10.1023/a:1020849700028

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 254: Issue 1

Synthesis and biodistribution of ^99mTcN(CHIPDTC)₂ as a potential myocardial perfusion imaging agent

Authors:

JunBo Zhang

JunBo Zhang Beijing Normal University Department of Chemistry Beijing 100875 P. R. China

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XueBin Wang

XueBin Wang Beijing Normal University Department of Chemistry Beijing 100875 P. R. China

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ChunYun Li

ChunYun Li Beijing Normal University Department of Chemistry Beijing 100875 P. R. China

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Pages:: 99–101

Online Publication Date:: 22 Dec 2004

Publication Date:: 17 Oct 2002

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1020849700028

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Abstract

The bis(N-cyclohexyl, N-isopropyl dithiocarbamato) nitrido technetium-99m complex [^99mTcN(CHIPDTC)₂] (CHIPDTC: N-cyclohexyl, N-isopropyl dithiocarbamato) has been synthesized through a ligand-exchange reaction. The two-step procedure involved the initial reaction of ^99mTcO₄^- with succinic dihydrazide (SDH) in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid (PDTA) as complexant, followed by the addition of the sodium salt of N-cyclohexyl, N-isopropyl dithiocarbamate. The radiochemical purity (RCP) of the complex was 96±2% as measured by thin layer chromatography (TLC). No decomposition of the complex at room temperature (r. t.) was observed within a period of 6 hours. Its partition coefficient indicated that it was a lipophilic complex. The electrophoresis results showed that the complex was neutral. Biodistribution in mice indicated that the complex accumulated in the heart with high uptake and good retention. The heart/blood, heart/lung ratio was 6.28 and 1.35, respectively, at 60-minute post-injection, suggesting that it would be a potential myocardial perfusion imaging agent.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)