Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 254: Issue 2
A preliminary study of new imaging agents on inflammatory lesions
Authors:
Chu Jinfeng Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Chu Jinfeng in
Current site
Google Scholar
PubMed Close
,
Wang Xuebin Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Wang Xuebin in
Current site
Google Scholar
PubMed Close
,
Lv Gongxu Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Lv Gongxu in
Current site
Google Scholar
PubMed Close
,
Zhao Yi Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Zhao Yi in
Current site
Google Scholar
PubMed Close
,
Zhang Junbo Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Zhang Junbo in
Current site
Google Scholar
PubMed Close
,
Wang Jincheng Beijing Anzhen Hospital Department of Nuclear Medicine Beijing 100029 P.R. China

Search for other papers by Wang Jincheng in
Current site
Google Scholar
PubMed Close
,
Mi Hongzhi Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Mi Hongzhi in
Current site
Google Scholar
PubMed Close
, and
Yang Hao Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

Search for other papers by Yang Hao in
Current site
Google Scholar
PubMed Close
Pages:
397–400
Online Publication Date:
01 Nov 2004
Publication Date:
17 Nov 2002
Article Category:
Research Article
DOI:
https://doi.org/10.1023/a:1021613008631
Restricted access

Abstract  

The purpose of the investigation was to evaluate the feasibility of imaging inflammatory lesions with five small molecular weight complexes of 99mTc. The labeling yields of D-glucaric acid (D-Gca), citric acid (Cit), DL-malic acid (DL-Mal), L-malic acid (L-Mal) and tartaric acid (Tar) were all more than 90%. The percentage uptake/g tissue of them and 99mTc-pertechnetate (P) in mice with turpentine-induced abscesses and abscess/muscle (A/M), blood (A/B), liver (A/L), kidney (A/K) concentration ratios were calculated. The maximum A/M ratios were 4.02±0.21 (Cit, 3h), 4.30±0.77 (D-Gca, 3h), 4.04±0.21 (DL-Mal, 6h), 3.50±0.23 (L-Mal, 1h), 3.20±0.17 (Tar, 1h) and 3.23±0.41 (P, 1h) respectively. The scintigram was obtained in a rabbit with turpentine-induced abscess after 99mTc-D-Gca i.v. injection. Results demonstrated they all can accumulate in inflammatory lesions. Of them, 99mTc-D-Gca is probably a potential imaging agent on inflammatory lesions.

  • Collapse
  • Expand
Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Aug 2024 4 0 0
Sep 2024 8 0 0
Oct 2024 23 0 0
Nov 2024 9 0 0
Dec 2024 2 0 0
Jan 2025 0 0 0
Feb 2025 0 0 0