At energies £15 MeV, 64Cu is most readily produced using the 64Ni(p,n)64Cu reaction. Space restrictions in the TR-PET target selector required a target system of compact design that would still allow the quick and easy removal of the irradiated target. The target consists of a 64Ni-plated rhodium disc held in place by a threaded cooling assembly. For removal, the cooling block is rotated slightly, allowing the disc to fall into a shielding container. The nickel is dissolved and the 64Cu separated by anion exchange or electrochemical deposition. Yields of up to 330 mCi of radiochemically pure 64Cu have been obtained.