Enantioselective synthesis of no-carrier added (NCA) 6-[18F]Fluoro-L-Dopa

Duanzhi Yin; Lan Zhang; Ganghua Tang; Xiaolan Tang; Yongxian Wang

doi:10.1023/a:1024734402290

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 257: Issue 1

Enantioselective synthesis of no-carrier added (NCA) 6-[¹⁸F]Fluoro-L-Dopa

Authors:

Duanzhi Yin

Duanzhi Yin Chinese Academy of Sciences Shanghai Institute of Nuclear Research P.O. Box 800-204 Shanghai 201800 P. R. China

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Lan Zhang

Lan Zhang Chinese Academy of Sciences Shanghai Institute of Nuclear Research P.O. Box 800-204 Shanghai 201800 P. R. China

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Ganghua Tang

Ganghua Tang Chinese Academy of Sciences Shanghai Institute of Nuclear Research P.O. Box 800-204 Shanghai 201800 P. R. China

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Xiaolan Tang

Xiaolan Tang The First Military Medical University Nanfang PET Center, Nanfang Hospital Guangzhou 510515 P. R. China

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, and

Yongxian Wang

Yongxian Wang

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Pages:: 179–185

Online Publication Date:: 31 Oct 2004

Publication Date:: 17 Jul 2003

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1024734402290

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Abstract

6-[¹⁸F]Fluoro-L-Dopa (6-FDOPA) is the analogue of L-Dopa, the biosynthesis precursor for dopamine. As a PET tracer, it was widely applied for the presynaptic dopamine function studies in human brain. The application of a chiral phase-transfer-catalyst (PTC) in enantioselective synthesis of N.C.A. 6-[¹⁸F]Fluoro-L-Dopa has been developed recently. An improved procedure was described in this study. The labeling precursor (6-Trimethylammoniumveratraldehyde Triflate) and PTC (O-Allyl-N-(9)-anthracenylcinchonidinium Bromide) were synthesized. A successful synthesis route was developed for the preparation of 6-[¹⁸F]Fluoro-L-Dopa with high radiochemical yields (4-9%, decay uncorrected) and short synthesis time(80min). The radiochemical purity was over 99% and no D-isomer was detected by HPLC analysis using a chiral mobile phase.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)