Vascular responses to endovascular irradiation of 188Re in the rabbit model after angioplasty

Wen-Jin Cherng; Bor-Tsung Hsieh; Chao-Hung Wang; Ming-Jui Hung; K. Cheng; Tsu-Tsen Yen; Ning Lee

doi:10.1023/a:1024711224580

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 257: Issue 2

Vascular responses to endovascular irradiation of ¹⁸⁸Re in the rabbit model after angioplasty

Authors:

Wen-Jin Cherng

Wen-Jin Cherng Institute of Nuclear Energy Research Taiwan

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Bor-Tsung Hsieh

Bor-Tsung Hsieh Institute of Nuclear Energy Research Taiwan

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Chao-Hung Wang

Chao-Hung Wang
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Ming-Jui Hung

Ming-Jui Hung Chang-Gung Memorial Hospital Taiwan

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K. Cheng

K. Cheng Chang-Gung Memorial Hospital Taiwan

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Tsu-Tsen Yen

Tsu-Tsen Yen Chang-Gung Memorial Hospital Cardiology Section, Department of Medicine, Department of Nuclear Medicine Taiwan

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Ning Lee

Ning Lee Chang-Gung Memorial Hospital Department of Pathology Taiwan

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Pages:: 255–260

Online Publication Date:: 31 Oct 2004

Publication Date:: 17 Aug 2003

Article Category:: Research Article

DOI:: https://doi.org/10.1023/a:1024711224580

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Abstract

The effects on vascular restenosis of intravascular radiation delivery from ¹⁸⁸Rhenium (Re)-perrhenate liquid-filled balloon through beta-particle radiation are controversial. To determine the effect of beta-radiation on vascular injury in hypercholesterolemic rabbits, thirty rabbits fed with a high cholesterol diet were enrolled into this study. All the rabbits underwent percutaneous transluminal balloon overstretch over left iliac artery. After balloon overstretch, the catheter was withdrawn and immediately followed by irradiation using low dose ¹⁸⁸Re solution (10 Gray) in the vascular wall 0.5 mm distal to intimal surface. After 2 and 6 weeks, arteries were harvested for histological and immunological analysis. This rabbit study suggest that endovascular ¹⁸⁸Re low dose irradiation at the non-injury segment of iliac artery may enhance intima hyperplasia and smooth muscle cell proliferation.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)