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  • 1 Pakistan Institute of Nuclear Science and Technology Isotope Production Division P.O. Box Nilore, Islamabad Pakistan
  • 2 Bahauddin Zakariya University Multan Pakistan
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Abstract  

The synthesis of 188Re-MAG3 is described using 188Re, which was obtained from the alumina based 188W/188Re generator. Dependence of the radiolabeling yields of 188Re-MAG3 on reducing agent concentration, Bz-MAG3 concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-MAG3 was 98%. TLC and HPLC techniques were employed to monitor the different species formed. Biodistribution study of 188Re-MAG3 was carried out in rats and compared with behavior of 99mTc-MAG3.