Authors:
Z. Kassai Water Research Institute Nábr. arm. gen. L. Svobodu 5 849 12 Bratislava Slovakia

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V. Koprda Slovak University of Technology Department of Environmental Science, Faculty of Chemical and Food Technology Radlinského 9 812 37 Bratislava Slovakia

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K. Bauerová Slovak Academy of Science Dúbravská cesta 9 842 16 Bratislava Slovakia

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M. Harangozó Slovak University of Technology Department of Environmental Science, Faculty of Chemical and Food Technology Radlinského 9 812 37 Bratislava Slovakia

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P. Bendová Slovak University of Technology Department of Environmental Science, Faculty of Chemical and Food Technology Radlinského 9 812 37 Bratislava Slovakia

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A. Bujnová Slovak University of Technology Department of Environmental Science, Faculty of Chemical and Food Technology Radlinského 9 812 37 Bratislava Slovakia

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A. Kassai Water Research Institute Nábr. arm. gen. L. Svobodu 5 849 12 Bratislava Slovakia

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Abstract  

The composition and the permeation properties of the skin are dependent on age. In the animal models for permation studies, age affects the mechanical as well as the permeation properties significantly. The time dependence of permeation of 147Pm3+ from aqueous solution was established by the animal skin model and the age dependence of promethium permeation through the skin was examined. The aim was to find the optimum rat skin age model for radionuclide permeation studies and to assess the relative importance of the main permeation pathways: transepidermal and transfollicular permeation. The skin from 5-day-old rats (5DR) was found to represent the optimum animal model to study transepidermal permeation of ions. The skin from 9-day-old rats (9DR) was selected to study transfollicular permeation of ions. Comparison of the permeated amounts of promethium through the skin without hairs (3 DR to 6 DR) and with hairs (7DR to 12DR) showed that the additional permation mode via follicles significantly contributed to the permeation rate and extent.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)