Hemispherical dominance of glucose metabolic rate in the brain of the 'normal' ageing population

D. Cutts; R. Maguire; K. Leenders; N. Spyrou

doi:10.1023/b:jrnc.0000017302.40092.db

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 259: Issue 2

Hemispherical dominance of glucose metabolic rate in the brain of the 'normal' ageing population

Authors:

D. Cutts

D. Cutts University of Surrey Guildford Physics Department Surrey GU2 5XH UK

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R. Maguire

R. Maguire Academic Hospital Groningen Hanzeplein 1 NL-9700 RB Groningen The Netherlands

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K. Leenders

K. Leenders Academic Hospital Groningen Hanzeplein 1 NL-9700 RB Groningen The Netherlands

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N. Spyrou

N. Spyrou University of Surrey Guildford Physics Department Surrey GU2 5XH UK

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Pages:: 277–280

Online Publication Date:: 16 Aug 2006

Publication Date:: 01 Feb 2004

Article Category:: Research Article

DOI:: https://doi.org/10.1023/b:jrnc.0000017302.40092.db

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Abstract

In the 'normal' ageing brain a decrease in the cerebral metabolic rate has been determined across many brain regions. This study determines whether age differences would affect metabolic rates in regions and different hemispheres of the brain. The regional metabolic rate of glucose (rCMRGlu) was examined in a group of 72 subjects, ages 22 to 82 years, with 36 regions of interest chosen from both hemispheres of the cortex, midbrain and cerebellum. To determine metabolic rates the in-vivo technique of positron emission tomography (PET) was employed. Three age groups were chosen to compare hemispherical differences. In both young and intermediate age groups the left hemisphere had higher rCMRGlu values than those of the right for the majority of regions with, although less pronounced in the intermediate group. Importantly, the older age group displayed little difference between hemispheres.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)