Determination of leachable arsenic from glass ampoules

S. Kayasth; K. Swain

doi:10.1023/b:jrnc.0000017305.84666.86

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 259: Issue 2

Determination of leachable arsenic from glass ampoules

Authors:

S. Kayasth

S. Kayasth Bhabha Atomic Research Centre Mumbai 400085 India

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and

K. Swain

K. Swain Bhabha Atomic Research Centre Mumbai 400085 India

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Pages:: 293–294

Online Publication Date:: 16 Aug 2006

Publication Date:: 01 Feb 2004

Article Category:: Research Article

DOI:: https://doi.org/10.1023/b:jrnc.0000017305.84666.86

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Abstract

Appreciable amounts of different arsenic compounds are used in the manufacture of glass and glass ampoules (injection vials and bottles) used to store drugs. Exposure/intake of arsenic to human beings may result in skin ulceration, injury to mucous membranes, perforation of nasal septum, skin cancer and keratoses, especially of the palms and soles and may cause detrimental effects. Considering the toxicity of arsenic, even if traces of arsenic from such glass containers/ampoules are leached out, it can impart damage to human beings. To check the possibility of leaching of arsenic from glass ampoules, a simple methodology has been developed. Different makes and varieties of glass ampoules filled with de-ionized water were subjected to high pressure and temperature leaching for varying amount of time using autoclave to create extreme conditions for the maximum leaching out of the analyte. Subsequently, the determination of the arsenic contents in leached water using neutron activation analysis is reported in this paper in detail with observations.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)