Radiochemical analysis of the polar agrochemicals validamycin and the metabolite melamine by ion-exchange chromatography

A. Fredenhagen

doi:10.1023/b:jrnc.0000034855.84999.1a

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 261: Issue 2

Radiochemical analysis of the polar agrochemicals validamycin and the metabolite melamine by ion-exchange chromatography

Author:

A. Fredenhagen

A. Fredenhagen Syngenta, Crop Protection, CPR Analytics R-1055.543 4002 Basel Switzerland

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Pages:: 249–253

Online Publication Date:: 03 Nov 2004

Publication Date:: 17 Aug 2004

Article Category:: Research Article

DOI:: https://doi.org/10.1023/b:jrnc.0000034855.84999.1a

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Abstract

Suitable analytical methods to determine the radiochemical purity of validamycin and melamine are not described in the literature. High performance ion-exchange chromatography for the detection of underivatized validamycin and melamine has been proposed. The compounds were separated on HPLC using a styrene-divinylbenzene copolymer based cation-exchanger. For the separation of validamycin a resin in the hydrogen-form has given a good separation and for melamine in the Na⁺-form. For the first time an ion-exchange separation of validamycin is described allowing the separation of at least four components of commercial validamycin: validamycin A, validamycin B or G, validoxylamine A and validoxylamine B or G without prior derivatization. The methods were applied to determine the radiochemical purity of ¹⁴C- or ³H labeled compounds.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)