Radiohalogenation of terguride via organotin intermediate

R. Tinková; L. Lešetický

doi:10.1023/b:jrnc.0000034883.18036.af

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 261: Issue 2

Radiohalogenation of terguride via organotin intermediate

Authors:

R. Tinková

R. Tinková Charles University in Prague Department of Organic and Nuclear Chemistry Hlavova 8 128 40 Praha 2 Czech Republic

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L. Lešetický

L. Lešetický Charles University in Prague Department of Organic and Nuclear Chemistry Hlavova 8 128 40 Praha 2 Czech Republic

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Pages:: 443–449

Online Publication Date:: 03 Nov 2004

Publication Date:: 17 Aug 2004

Article Category:: Research Article

DOI:: https://doi.org/10.1023/b:jrnc.0000034883.18036.af

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Abstract

New (radio)halogen derivatives of 1-allylterguride have been prepared by method of destannylation-halogenation. 1-Alylterguride shows relatively high binding affinity, which can be used in the case of its radiolabeled derivatives with imaging methods like PET or SPET in studies of properties of receptor's binding places and ligand affinity. The (radio)halogenation was performed via organotin precursors: 1-tributylstannyl-3-chlorprop-1-ene and 2-tributylstannyl-3-chloroprop-1-ene, which were prepared from appropriate alcohols. Linkers of the tin group were used for alkylation of N1 of terguride both under microwave irradiation and under conventional heating. In the last step (destannylation-halogenation), fluoro-, bromo- and iododerivatives as well as ¹²⁵I iodo- and ⁸²Br bromoderivatives of 1-allylterguride were obtained.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)