Determination of elemental and radionuclidic impurities in 177Lu used for labeling of radiopharmaceuticals

D. Pawlak; J. Parus; I. Sasinowska; R. Mikolajczak

doi:10.1023/b:jrnc.0000034887.23530.f6

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 261: Issue 2

Determination of elemental and radionuclidic impurities in ¹⁷⁷Lu used for labeling of radiopharmaceuticals

Authors:

D. Pawlak

D. Pawlak Radioisotope Centre POLATOM, 05-400 Otwock Świerk Poland

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J. Parus

J. Parus Radioisotope Centre POLATOM, 05-400 Otwock Świerk Poland

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I. Sasinowska

I. Sasinowska Radioisotope Centre POLATOM, 05-400 Otwock Świerk Poland

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, and

R. Mikolajczak

R. Mikolajczak Radioisotope Centre POLATOM, 05-400 Otwock Świerk Poland

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Pages:: 469–472

Online Publication Date:: 03 Nov 2004

Publication Date:: 17 Aug 2004

Article Category:: Research Article

DOI:: https://doi.org/10.1023/b:jrnc.0000034887.23530.f6

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Abstract

We describe an analytical procedure with the use of inductively coupled plasma optical emission spectrometry (ICP-OES) for the determination of about 20 elements in solutions of ¹⁷⁷LuCl₃ following the dissolution of the irradiated lutetium nitrate or oxide. The aliquots containing amounts of lutetium ranging from 1 to 100 µg in 1 ml volume were analyzed. It corresponded to the activity of ¹⁷⁷Lu ranging from 5 to 100 mCi. The detection limits of the elements concerned were in the range of 1 to 100 ng·ml^–1. The activity of ¹⁷⁷Lu and other radionuclides was measured using a high-resolution gamma ray spectrometer. The developed procedures are to be used for routine quality control of ¹⁷⁷Lu produced for synthesis of radiopharmaceuticals.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)