Synthesis and biodistribution of 99mTcN(PDTC)2as a potential brain imaging agent

JunBo Zhang; XueBin Wang; ChunJun Tian

doi:10.1023/b:jrnc.0000046787.02935.e2

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 262: Issue 2

Synthesis and biodistribution of ^99mTcN(PDTC)₂as a potential brain imaging agent

Authors:

JunBo Zhang

JunBo Zhang Beijing Normal University Beijing Department of Chemistry 100875 P.R. China E-mail

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XueBin Wang

XueBin Wang Beijing Normal University Beijing Department of Chemistry 100875 P.R. China E-mail

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ChunJun Tian

ChunJun Tian Beijing Normal University Beijing Department of Chemistry 100875 P.R. China E-mail

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Pages:: 505–507

Online Publication Date:: 07 Dec 2004

Publication Date:: 01 Nov 2004

Article Category:: Research Article

DOI:: https://doi.org/10.1023/b:jrnc.0000046787.02935.e2

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Abstract

The preparation of the bis(N-propyl dithiocarbamato) nitrido technetium-99m complex ^99mTcN(PDTC)₂ (PDTC: N-propyl dithiocarbamato) was carried out as a freeze-dried formulation, through a simple procedure involving the initial of ^99mTcO_4- with succinic dihydrazide in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid (PDTA) as complexant, followed by the addition of the ligand sodium salt of N-propyl dithiocarbamate to afford the final product. The radiochemical purity of the complex was over 90%, as measured by thin layer chromatography. No decomposition of the complex at room temperature was observed over a period of 12 hours. Its partition coefficient indicated that it was a good lipophilic complex. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain uptake (ID%/g) was 5.07 and the brain/blood ratio 1.34 at 5-minute post-injection. This suggested a potential usefulness of the complex as a brain perfusion imaging agent.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)