Authors:
A. N. Garg Department of Chemistry, Indian Institute of Technology Roorkee-247 667, India

Search for other papers by A. N. Garg in
Current site
Google Scholar
PubMed
Close
,
A. Kumar Department of Chemistry, Indian Institute of Technology Roorkee-247 667, India

Search for other papers by A. Kumar in
Current site
Google Scholar
PubMed
Close
,
G. Maheshwari Department of Chemistry, Indian Institute of Technology Roorkee-247 667, India

Search for other papers by G. Maheshwari in
Current site
Google Scholar
PubMed
Close
, and
S. Sharma Department of Chemistry, Indian Institute of Technology Roorkee-247 667, India

Search for other papers by S. Sharma in
Current site
Google Scholar
PubMed
Close
Restricted access

Summary  

Radioanalytical techniques have been applied in a study on (subclinical) hepatitis in Dobermann dogs. Cu levels in transcutaneous obtained full liver biopsies were quantified using INAA and 66Cu. A copper excretion study was performed in a group of completely normal Dobermann dogs and in six Dobermanns with elevated copper levels and suffering from subclinical hepatitis. 64Cu2+ was used to assess whether a normal bile flow and thus excretion was possible. All subjects underwent separately from this 64Cu2+ excretion study a 99mTc-Bis-IDA scintigraphy. The Cu levels in liver of these hepatitis patients vary from 600 to 1600 mg . kg-1 whereas 100-300 mg . kg-1 is probably normal for healthy Dobermann dogs. These Cu levels match fully with histopathology results and clinical observations. Measurements during a 2 years' evaluation period showed a clear relation between the existence of subclinical hepatitis and increased Cu levels without a sign for cholestasis or an abnormal bile flow.

  • Collapse
  • Expand

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)