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  • 1 Nuclear Medicine Program, Nuclear Science and Technology Division, Oak Ridge National Laboratory (ORNL) P.O. Box 2008, Oak Ridge, Tennessee, 37831-6229, USA
  • | 2 Nuclear Medicine Program, Nuclear Science and Technology Division, Oak Ridge National Laboratory (ORNL) P.O. Box 2008, Oak Ridge, Tennessee, 37831-6229, USA
  • | 3 Nuclear Medicine Program, Nuclear Science and Technology Division, Oak Ridge National Laboratory (ORNL) P.O. Box 2008, Oak Ridge, Tennessee, 37831-6229, USA
  • | 4 Nuclear Medicine Program, Nuclear Science and Technology Division, Oak Ridge National Laboratory (ORNL) P.O. Box 2008, Oak Ridge, Tennessee, 37831-6229, USA
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Summary  

Greater availability of therapeutic radioisotopes is required to meet the demands for increasing clinical applications in nuclear medicine, oncology and interventional cardiology. Because of the need for very high specific activity products, methods other than direct neutron capture reactions (n,γ-elastic and n,n’-inelastic routes) are required to insure that the highest specific activity - and hopefully no carrier added (nca) - radioisotopes are available. Two major methods to obtain nca radioisotopes from reactors are through the use of radionuclide generator systems using reactor-produced parents and the formation of desired radioisotopes through beta-decay of reactor-produced species. In this paper we describe our recent development of new approaches to obtain nca 177Lu from the decay of reactor-produced 177Yb and free of the long-lived 177mLu (T1/2 = 160 d) radiocontaminant. We also describe preliminary results of our new “indirect” method for the production of 195mPt via decay of 195mIr, reactor-produced by neutron irradiation of highly enriched 193Ir.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)