Analytical and radioanalytical quality control of purity and stability of radiopharmaceutical compound [186gRe]Re-HEDP for bone metastases pain palliation

D. Bagatti; M. C. Cantone; A. Giussani; S. Ridone; C. Birattari; M. L. Bonardi; F. Groppi; A. Martinotti; S. Morzenti; M. Gallorini; E. Rizzio

doi:10.1007/s10967-005-0617-9

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 263: Issue 2

Analytical and radioanalytical quality control of purity and stability of radiopharmaceutical compound [^186gRe]Re-HEDP for bone metastases pain palliation

Authors:

D. Bagatti

D. Bagatti Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics Via Celoria 16, I-20133 Milano, Italy

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M. C. Cantone

M. C. Cantone Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics Via Celoria 16, I-20133 Milano, Italy

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A. Giussani

A. Giussani Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics Via Celoria 16, I-20133 Milano, Italy

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S. Ridone

S. Ridone Universitá degli Studi di Milano, Department of Physics, Section of Medical Physics Via Celoria 16, I-20133 Milano, Italy

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C. Birattari

C. Birattari Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy

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M. L. Bonardi

M. L. Bonardi Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy

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F. Groppi

F. Groppi Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy

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A. Martinotti

A. Martinotti Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy

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S. Morzenti

S. Morzenti Radiochemistry Laboratory, LASA, Universitá degli Studi and INFN Via F.lli Cervi 201, I-20090 Segrate, Milano, Italy

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M. Gallorini

M. Gallorini Unit of Radiochemistry and Spectroscopy, CNR and University of Pavia Via Taramelli 12, I-27100 Pavia, Italy

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, and

E. Rizzio

E. Rizzio Unit of Radiochemistry and Spectroscopy, CNR and University of Pavia Via Taramelli 12, I-27100 Pavia, Italy

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Pages:: 515–520

Online Publication Date:: 26 Aug 2005

Publication Date:: 17 Jan 2005

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-005-0617-9

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Summary

The nuclear properties of ^186gRe make it a useful agent for radionuclide therapy and imaging. The coordination compound [^186gRe]Re-HEDP has proved to be a successful bone seeking agent for palliation of metastatic bone pain. Chemical, radiochemical and radionuclidic purity of commercial radiopharmaceutical [^186gRe]Re-HEDP have been checked by means by γ- and β-spectrometries, INAA and paper radio-chromatography. The results indicate a good radionuclidic purity, with levels of contamination from the short-lived ¹⁸⁸Re well below the required specifications. After injection of the radiopharmaceutical, the radiochemical measurements conducted in vivo, on biological matrices, blood, plasma and urine, have shown that, entering the systemic circulation, ^186gRe dissociates from the bis-phosphonate complex as hydrosoluble [^186gRe]ReO₄-, and the two chemical species follow different biokinetics.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)