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  • 1 Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University Beijing 100871, P.R. China
  • 2 Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University Beijing 100871, P.R. China
  • 3 Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University Beijing 100871, P.R. China
  • 4 Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University Beijing 100871, P.R. China
  • 5 Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University Beijing 100871, P.R. China
  • 6 Institute of Heavy Ion Physics, School of Physics, Peking University Beijing 100871, P.R. China
  • 7 Institute of Heavy Ion Physics, School of Physics, Peking University Beijing 100871, P.R. China
  • 8 Institute of Heavy Ion Physics, School of Physics, Peking University Beijing 100871, P.R. China
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Summary  

Accelerator mass spectrometry (AMS) is an ultra-sensitive method to monitor and trace the environmental exposure levels of 14C-labeled molecules in vivo. Nicotine [3-(1-methyl-2-pyrrolidinyl)-pyridine], a major alkaloid in tobacco products, has proven to be a potential genotoxic compound. Using 14C-labeled nicotine and AMS, we have investigated the inhibitory effect of curcumin, garlic squeeze, grapeseed extract, tea polyphenols, vitamin C and vitamin E, respectively, on nicotine-hemoglobin (Hb) adduction in vivo. The results demonstrated that these dietary constituents induced remarkable decrease of nicotine-Hb adducts. The inhibitory fact may afford an important clue of the chemoprevention of the potential nicotine-induced carcinogenesis.