Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 265: Issue 1
Synthesis of [14C] quincetone
Authors:
Li Yu-guo Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences P.O. Box 201800, Shanghai, P.R. China

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Huang Xuan Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences P.O. Box 201800, Shanghai, P.R. China

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Liu Riu-li Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences P.O. Box 201800, Shanghai, P.R. China

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Li Qing-nuan Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences P.O. Box 201800, Shanghai, P.R. China

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Zhang Xiao-dong Shanghai Jiaotong University of Chinese P.O. Box 200030, Shanghai, P.R. China

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Li Wen-xin Laboratory of Nanoscale Biomedicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences P.O. Box 201800, Shanghai, P.R. China

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Pages:
127–131
Online Publication Date:
08 Sep 2005
Publication Date:
17 Jun 2005
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-005-0802-x
Restricted access

Summary  

The water-soluble fullerene derivative C60(OH)x was radiolabeled with 67GaCl3. The labeling yields were determined by radio-PLC. The effects of pH, reaction time, temperature and the amount of C60(OH)x on the labeling yields were studied. The stability of 67Ga-C60(OH)x was also examined. The results showed that the labeling yields could reach 97% under the best labeling conditions and the radiochemical purity of 67Ga-C60(OH)x solution kept at 37 °C remained at 88% after 212 hours. The biodistribution studies of 67Ga-C60(OH)x in mice showed a high localization of 67Ga-C60(OH)x in the bone marrow, bone, liver and spleen with slow clearance and a negligible accumulation in the blood. These data suggest that the water-soluble C60(OH)x, having the same properties as microcolloids, may be used as a carrier of drug system for lymphatic targeting.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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