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  • 1 Department of Chemistry, Beijing Normal University Beijing, 100875, P.R. China
  • | 2 Northwest Institute of Nuclear Technology Xi’an ShannXi, 710024, P.R. China
  • | 3 Department of Nuclear Medicine, The PLA General Hospital Beijing, 100853, P.R. China
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Summary  

In order to develop small molecular probes for imaging of Aβ plaques in the brain with Alzheimer’s disease, four benzothiazole derivatives as Aβ probes, 3’-125I-BTA, 3’-125I-CBTA, 3’-125I-BTA-Ac, and 3’-125I-CBTA-Ac were successfully prepared. The four probes displayed the following initial brain uptake: 10.28 %ID/g, 3.62 %ID/g, 3.33 %ID/g and 3.71 %ID/g at 2-minute post iv injection, respectively. The study of quantitative structure-activity relationship (QSAR) indicated that the initial brain uptake was correlated with molecule volume (Vm) and dipole moment (Dp), but the Dp was the main factor. 3’-125I-BTA has the highest initial brain uptake among the four Aβ probes because of the smallest Dp.

Manuscript Submission: HERE

  • Impact Factor (2019): 1.137
  • Scimago Journal Rank (2019): 0.360
  • SJR Hirsch-Index (2019): 65
  • SJR Quartile Score (2019): Q3 Analytical Chemistry
  • SJR Quartile Score (2019): Q3 Health, Toxicology and Mutagenesis
  • SJR Quartile Score (2019): Q2 Nuclear Energy and Engineering
  • SJR Quartile Score (2019): Q3 Pollution
  • SJR Quartile Score (2019): Q3 Public Health, Environmental and Occupational Health
  • SJR Quartile Score (2019): Q3 Radiology, Nuclear Medicine and Imaging
  • SJR Quartile Score (2019): Q3 Spectroscopy
  • Impact Factor (2018): 1.186
  • Scimago Journal Rank (2018): 0.408
  • SJR Hirsch-Index (2018): 60
  • SJR Quartile Score (2018): Q2 Nuclear Energy and Engineering
  • SJR Quartile Score (2018): Q2 Pollution

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
4
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)