Authors:
Shahid PervezIsotope Production Division, Pakistan Institute of Nuclear Science and Technology P.O. Nilore, Islamabad, Pakistan

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A. MushtaqIsotope Production Division, Pakistan Institute of Nuclear Science and Technology P.O. Nilore, Islamabad, Pakistan

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Summary  

Lanreotide, a synthetic octapeptide analog of a native hormone somatostatin, was labeled with 131I, the most widely used therapeutic and easily available radionuclide. Radioiodination of Lanreotide was carried out by Chloramine-T and Iodogen methods. Chloramine-T and Iodogen were used as oxidizing agents to form an electrophilic iodine species, which then labeled the tyrosine of Lanreotide. The maximum radiolabeling yield was ~80%. Chloramine-T was found more suitable than the Iodogen method, because nearly 25% of the initial iodine activity was lost/adsorbed on the Iodogen coating. Thin layer and high performance liquid chromatographies were used for monitoring the reaction of 131I with Lanreotide, the stability and purity of 131I-Lanreotide.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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