[11C]-choline has been reported as a potential tracer for imaging a variety of human tumors with positron emission tomography
(PET). A new labeling technique for [11C]-choline was established depending on parameters optimized, such as reaction time, volume, temperature, and the quantity
of DMAE.The synthesis yield was improved from 82.0% to 96.5% (EOB), while the consumption of DMAE precursor decreased from
60 to 2 mg. Absolute yield of [11C]-choline was 2500 MBq for a 10-minute irradiation at15mA, and a total synthesis time of less than 8 minutes from [11C]-CH3I to [11C]-choline.