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  • 1 Department of Chemistry, Normal University; PET Center, PLA General Hospital 100875, Beijing, P.R. China; 100853, Beijing, P.R. China
  • | 2 PET Center, PLA General Hospital 100853, Beijing, P.R. China
  • | 3 Department of Chemistry, Normal University 100875, Beijing, P.R. China
  • | 4 Department of Chemistry, Normal University 100875, Beijing, P.R. China
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Summary  

[11C]-choline has been reported as a potential tracer for imaging a variety of human tumors with positron emission tomography (PET). A new labeling technique for [11C]-choline was established depending on parameters optimized, such as reaction time, volume, temperature, and the quantity of DMAE.The synthesis yield was improved from 82.0% to 96.5% (EOB), while the consumption of DMAE precursor decreased from 60 to 2 mg. Absolute yield of [11C]-choline was 2500 MBq for a 10-minute irradiation at15mA, and a total synthesis time of less than 8 minutes from [11C]-CH3I to [11C]-choline.