Authors:
M. S. Casare Lab. de Química de Proteínas, Centro de Biologia Molecular, Instituto de Pesquisas Energéticas e Nucleares Av. Lineu Prestes 2242, 05508-900 S?o Paulo, Brazil

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P. Spencer Lab. de Química de Proteínas, Centro de Biologia Molecular, Instituto de Pesquisas Energéticas e Nucleares Av. Lineu Prestes 2242, 05508-900 S?o Paulo, Brazil

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L. A. Campos Lab. de Química de Proteínas, Centro de Biologia Molecular, Instituto de Pesquisas Energéticas e Nucleares Av. Lineu Prestes 2242, 05508-900 S?o Paulo, Brazil

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N. Nascimento Lab. de Química de Proteínas, Centro de Biologia Molecular, Instituto de Pesquisas Energéticas e Nucleares Av. Lineu Prestes 2242, 05508-900 S?o Paulo, Brazil

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Summary  

Crotoxin is a 23 kDa neurotoxin from Crotalus durissus terrificus and is composed of a 9 kDa acidic subunit (crotapotin) and a 14 kDa basic subunit (phospholipase A2). Crotamine is 4882 Da, basic polypeptide with myotoxic activity. These toxins, when submitted to gamma-rays, in aqueous solution, present structural modifications, preserving their immunogenic properties. In the present work, we investigated some structural modifications on both crotoxin and crotamine after gamma-radiation using various doses, in the presence or not of “scavenger” substances. Our results indicate that irradiation leads to progressive changes in the structure of the toxin, which could explain the lower toxicity observed.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)