Synthesis and biodistribution of the 99mTc(CO)3-DEDT complex as a potential new radiopharmaceutical for brain imaging

JunBo Zhang; XueBin Wang; Can Jin

doi:10.1007/s10967-006-6794-3

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 272: Issue 1

Synthesis and biodistribution of the ^99mTc(CO)₃-DEDT complex as a potential new radiopharmaceutical for brain imaging

Authors:

JunBo Zhang

JunBo Zhang Beijing Normal University Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry Beijing 100875 P. R. China

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XueBin Wang

XueBin Wang Beijing Normal University Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry Beijing 100875 P. R. China

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, and

Can Jin

Can Jin Beijing Normal University Key Laboratory of Radiopharmaceuticals (Beijing Normal University), Ministry of Education, Department of Chemistry Beijing 100875 P. R. China

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Pages:: 91–94

Online Publication Date:: 03 Feb 2007

Publication Date:: 01 Apr 2007

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-006-6794-3

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Abstract

The ^99mTc(CO)₃(H₂O)-DEDT complex was prepared by a two-step procedure involving the preparation of the precursor fac-[^99mTc(CO)₃(H₂O)₃]⁺, followed by the addition of sodium salt of diethyl dithiocarbamate (DEDT). The radiochemical purity (RCP) of the product was over 90% as measured by thin layer chromatography (TLC). No decomposition of the complex at room temperature was observed over a period of 6 hours. Its partition coefficient indicated that it was a lipophilic complex. The electrophoresis results showed the complex was neutral. Biodistribution in mice demonstrated that the complex can penetrate the intact blood-brain barrier (BBB) and the brain uptake (ID%/g) was 4.22 at 5-minute post-injection, suggesting the complex may lead to a further development of the radiopharma ceutical as a brain perfusion tracer.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)