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  • 1 Chinese Academy of Sciences Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics Beijing 100049 P.R. China
  • 2 Graduate School of the Chinese Academy of Sciences Beijing 100049 P.R. China
  • 3 Shenzhen University Institute of Nuclear Technology Shenzhen 518060 P.R. China
  • 4 Beijing Synchrotron Radiation Facility Beijing 100049 P.R. China
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Abstract  

To investigate the effects of lanthanum exposure on regional distribution of inorganic elements in rat brain. Wistar rats were exposed to lanthanum chloride through oral administration at 0, 0.1, 2, and 40 mg/kg concentration for 6 months. The elements such as Cl, K, Ca, Fe, Cu, and Zn were identified in the brain slices by synchrotron radiation X-ray fluorescence (SRXRF) analysis. Differences of brain elemental distributions were noticed. Cl, Ca, and Zn were primarily concentrated in hippocampus of the controls. With the increase of the lanthanum dosage, the Ca and Zn levels significantly decreased, while the Cu levels significantly elevated in cortex, hippocampus and thalamus. Our results suggest that subchronic lanthanum exposure in rats appears to change elemental distributions in brain.