Radiolabeling and in vitro evaluation of the polystyrene particles as a promising probe in biomedical sciences

J. Chen; M. Tan; G. Zhang; Y. Li

doi:10.1007/s10967-007-0533-2

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 272: Issue 2

Radiolabeling and in vitro evaluation of the polystyrene particles as a promising probe in biomedical sciences

Authors:

J. Chen

J. Chen

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M. Tan

M. Tan Chinese Academy of Sciences Shanghai Institute of Applied Physics Shanghai 201800 P.R. China

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G. Zhang

G. Zhang Chinese Academy of Sciences Shanghai Institute of Applied Physics Shanghai 201800 P.R. China

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Y. Li

Y. Li Chinese Academy of Sciences Shanghai Institute of Applied Physics Shanghai 201800 P.R. China

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Pages:: 387–390

Online Publication Date:: 27 Feb 2007

Publication Date:: 01 May 2007

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-007-0533-2

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Abstract

A simple direct labeling method was used to synthesize the iodinated ultrafine polystyrene particles. The assay of X-ray photoelectron spectroscopy (XPS) as well as Fourier-transform infrared (FT-IR) spectroscopy indicated the formation of stable covalent bond to aryl group of the polymer particles. The purified radioiodinated product was incubated with serum of rat, and then evaluated by in vitro stability test. The result showed that these synthesized ultrafine polystyrene particles were unmetabolized at 2 hours post-exposure, indicating the potential useful application of this labeled polymer particles as a promising probe in biomedical sciences.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)