Due to changes of the dietary pattern and life style, cardiovascular diseases like coronary heart disease (CHD) have been
increasing in Korea. In this study, the levels of the serum minerals such as Na, Cl, K, Ca, Fe, Zn and Se for 75 patients
with CHD and 25 normal persons, who were older than the age of 40, were investigated by instrumental neutron activation analysis.
For analytical quality control, the reference materials. INSPQ and Seronorm, were analyzed simultaneously. The relative errors
of the analytical values for the reference materials were within 10% of the certified values. The average concentrations of
Na, Cl, K, Ca, Fe, Zn and Se in the serum of the male patients were 2,850±260 mg/1, 3,400±310 mg/l, 160±30 mg/l, 80.9±11.7
mg/l, 1.57±0.73 mg/l, 0.094±0.019 mg/l and 0.795±0.163 mg/l, respectively. The concentrations of Na, Cl, K, Ca, Fe, Zn and
Se in the serum of the female patients were 2,890±240 mg/l, 3,430±350 mg/l, 169±27 mg/l, 81.8±13.0 mg/l, 1.26±0.44 mg/l, 0.099±0.015
mg/l and 0.769±0.105 mg/l, respectively. In a comparison between the patients and the normal group for both genders, while
the levels of the elemental concentrations such as Na, Cl, K, Ca, Fe and Se were similar, the Zn concentration level of the
CHD patients was significantly lower than that of the normal ones. The present study showed that the Zn concentration in the
serum could be associated with CHD in Korean adults.