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  • 1 Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049 P.R. China
  • | 2 Graduate School of the Chinese Academy of Sciences, Beijing, 100049 P.R. China
  • | 3 Synchrotron Radiation Facility Laboratory, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049 P.R. China
  • | 4 Institute of Nuclear Technology, Shenzhen University, Shenzhen, 518060 P.R. China
  • | 5 Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 P.R. China
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Abstract  

The characterization of different sized TiO2 (25 nm, 80 nm, and 155 nm) was carried out by transmission electron microscopy (TEM) and the micro-distributions of TiO2 in the olfactory bulb of mice after nasal inhalation were investigated by microbeam SRXRF mapping techniques. The results show that TiO2 particles can be translocated to the olfactory bulb through the olfactory nerve system after inhalation. The distributions of Fe, Cu, and Zn in the olfactory bulb were also studied.