The characterization of different sized TiO2 (25 nm, 80 nm, and 155 nm) was carried out by transmission electron microscopy (TEM) and the micro-distributions of TiO2 in the olfactory bulb of mice after nasal inhalation were investigated by microbeam SRXRF mapping techniques. The results
show that TiO2 particles can be translocated to the olfactory bulb through the olfactory nerve system after inhalation. The distributions
of Fe, Cu, and Zn in the olfactory bulb were also studied.