View More View Less
  • 1 Chinese Academy of Sciences Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics Beijing 100049 P.R. China
  • | 2 The Graduate University of Chinese Academy of Sciences Beijing 100049 P.R. China
  • | 3 National Center for Nanoscience and Nanotechnology, China Beijing 100081 P.R. China
Restricted access

Abstract  

Nanosized copper particles are widely used in fields of lubricants, polymers/plastic, metallic coating and ink. Recently, we found that copper particles in different sizes can lead to different toxicological effects. To clarify the target organs of copper particles of different sizes, the inductively coupled plasma mass spectroscopy (ICP-MS) was employed to evaluate the distribution of copper in different organs of mice after a single dose oral exposure. The results suggest that the main target organs for copper nanoparticles are kidney, liver and blood. Liver is the main damaged organ.