Synthesis of a bis-(N-butyl-dithiocarbamato)-nitrido 99mTc complex: A potential new brain imaging agent

JunBo Zhang; XueBin Wang; ChunJun Tian

doi:10.1007/s10967-007-0703-2

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 273: Issue 1

Synthesis of a bis-(N-butyl-dithiocarbamato)-nitrido ^99mTc complex: A potential new brain imaging agent

Authors:

JunBo Zhang

JunBo Zhang Beijing Normal University Key Laboratory of Radiopharmaceuticals, Ministry of Education; Department of Chemistry Beijing 100875 P.R. China

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XueBin Wang

XueBin Wang Beijing Normal University Key Laboratory of Radiopharmaceuticals, Ministry of Education; Department of Chemistry Beijing 100875 P.R. China

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, and

ChunJun Tian

ChunJun Tian Beijing Normal University Key Laboratory of Radiopharmaceuticals, Ministry of Education; Department of Chemistry Beijing 100875 P.R. China

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Pages:: 15–17

Online Publication Date:: 17 Jun 2007

Publication Date:: 01 Jul 2007

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-007-0703-2

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Abstract

The bis(N-butyl dithiocarbamato) nitrido ^99mTc complex [^99mTcN(BDTC)₂] (BDTC: N-butyl dithiocarbamato) has been synthesized through a ligand-exchange reaction. The two-step procedure consisted of an initial reaction of ^99mTcO₄⁻ with succinic dihydrazide (SDH) in the presence of stannous chloride as reducing agent and propylenediamine tetraacetic acid (PDTA) as complexing agent, and subsequent addition of sodium salt of N-butyl dithiocarbamate. The radiochemical purity of the complex was over 90%, as measured by thin layer chromatography. No decomposition of the complex at room temperature was observed over a period of 6 hours. Its partition coefficient indicated that it was a lipophilic complex. The electrophoresis results showed the complex was neutral. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain/blood ratio was 1.58, 1.67 and 1.20 at 5, 30 and 60-minute post-injection, respectively, suggesting this compound would be a potential cerebral imaging agent.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)