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  • 1 Peking University First Hospital Department of Nuclear Medicine Beijing 100034 P.R. China
  • 2 Beijing Normal University Department of Chemistry Beijing 100875 P.R. China
  • 3 Beijing Normal University Department of Inorganic Chemistry Beijing 100875 P.R. China
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Abstract  

To increase the tumor uptake of Val-Gly-Gly (VGG), adenine was introduced into the peptide. N-mercaptoacetyl-VGG-adenine (MAVGG-adenine) and MAVGG were labeled with 99mTc using a solution of SnCl2 and tartaric acid as reducing agent. Biodistribution in mice bearing the S180 tumor was measured and γ imaging was performed. Compared with MAVGG, adenine conjugated MAVGG had higher tumor uptake and tumor to normal tissue ratios, which suggested that the tumor uptake property of a peptide may be improved by introducing a nucleotide base. The high contrasted tumor images of 99mTc-MAVGG-adenine also suggested its potential utility as tumor imaging agent.