Synthesis and biodistribution of 99mTc-peptides conjugated adenine as tumor imaging agents

Y. Zhao; C. Zhang; C. Qi; S. Feng; G. You; Z. Fu; F. Guo; R. Wang

doi:10.1007/s10967-007-0702-3

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 273: Issue 1

Synthesis and biodistribution of ^99mTc-peptides conjugated adenine as tumor imaging agents

Authors:

Y. Zhao

Y. Zhao Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

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C. Zhang

C. Zhang Peking University First Hospital Department of Nuclear Medicine Beijing 100034 P.R. China

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C. Qi

C. Qi Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

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S. Feng

S. Feng Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

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G. You

G. You Beijing Normal University Department of Chemistry Beijing 100875 P.R. China

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Z. Fu

Z. Fu Peking University First Hospital Department of Nuclear Medicine Beijing 100034 P.R. China

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F. Guo

F. Guo Peking University First Hospital Department of Nuclear Medicine Beijing 100034 P.R. China

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R. Wang

R. Wang Peking University First Hospital Department of Nuclear Medicine Beijing 100034 P.R. China

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Pages:: 9–13

Online Publication Date:: 17 Jun 2007

Publication Date:: 01 Jul 2007

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-007-0702-3

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Abstract

Two peptide ligands conjugated adenine, [9-N-(tritylmercapto acetyl diglycyl aminoethyl) adenine, Tr-MAG₂-Ade] and [9-N-(tritylmercapto acetyl triglycyl aminoethyl) adenine, Tr-MAG₃-Ade], are synthesized and labeled with ^99mTc by directly labeling method. The stability of ^99mTc-MAG₂-adenine and ^99mTc-MAG₃-adenine in vitro is measured. The uptake radios of tumor to muscle at 3h post-injection are 5.70 and 4.92, respectively. The biodistribution and scintigraphic imaging studies show that the two complexes have high localization in tumor and high contrasted tumor images can be obtained, which suggest their potential utility as tumor imaging agents. But the high radioactivity of abdomen could prevent the tumor imaging in this area.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)