Distribution of 131I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats

O. Yilmaz; F. Lambrecht; N. Gokmen; S. Erbayraktar; K. Durkan

doi:10.1007/s10967-007-6859-y

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 273: Issue 2

Distribution of ¹³¹I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats

Authors:

O. Yilmaz

O. Yilmaz Dokuz Eylul University School of Medicine Department of Animal Research Center Izmir Turkey

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F. Lambrecht

F. Lambrecht Ege University Institute of Nuclear Sciences Department of Nuclear Applications Izmir Turkey

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N. Gokmen

N. Gokmen Dokuz Eylul University School of Medicine Department of Anesthesiology and Reanimation Izmir Turkey

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S. Erbayraktar

S. Erbayraktar Dokuz Eylul University School of Medicine Department of Neurosurgery Izmir Turkey

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K. Durkan

K. Durkan Ege University Institute of Nuclear Sciences Department of Nuclear Applications Izmir Turkey

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Pages:: 311–313

Online Publication Date:: 30 Jun 2007

Publication Date:: 01 Aug 2007

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-007-6859-y

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Abstract

The aim of the present study was to demonstrate the possible transplacental transmission of ¹³¹I labeled recombinant human erythropoietin (¹³¹I-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy of 18 days were used ¹³¹I labeled recombinant human erythropoietin (specific activity = 2.4 μCi/IU) was injected into the tail vein of rats. After 30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed. Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were followed by radioactivity count via Cd(Te) detector. ¹³¹I labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing in every fetus and its corresponding placenta.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)