Adsorption of long-lived 125Sb radioisotope (T1/2 = 2.75 y) on alumina (Al2O3) and titania (TiO2) has been studied at different pH. Both the oxides have good adsorption capability for the 125Sb radioisotopes but the TiO2 is much superior. Adsorption kinetics of 125Sb radioisotopes on TiO2 surface and desorption of 125Sb radioisotopes from TiO2 surface in acidic and alkaline media have also been studied. The 125Sb-TiO2 phase has been subjected to γ-irradiation and found to be radiation stable against antimony release.