Radiolabeled somatostatin analogues, including octreotate have been used for targeted radiotherapy of neuroendocrine tumors
such as lymphoma, breast cancer, small-cell lung cancer and melanoma. In this paper, studies on the optimization of the production
of 177Lu, 166Ho and 153Sm radionuclides in Pakistan Atomic Research Reactor (PARR-I) and the investigations on the labeling of DOTA-Tyr-3 Octreotate
with 131I, 177Lu, 166Ho and 153Sm have been reported. The labeled DOTA-Tyr3-Octreotate complexes were found to be stable in acetate/ascorbate buffer and
saline at room temperature (18–22°C). The biodistribution studies of 177Lu-DOTA-Tyr-3 Octreotate in rat model indicated that the critical organ for this complex was the pancreas and the excretion
route was through kidney.