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  • 1 Szeged University Department of Inorganic and Analytical Chemistry H-6701 Szeged P.O. Box 440 Hungary
  • 2 Szeged University Biocoordination Research Group of Hungarian Academy of Sciences, Department of Inorganic and Analytical Chemistry H-6701 Szeged P.O. Box 440 Hungary
  • 3 Fukuoka University Department of Chemistry, Faculty of Science Fukuoka, Nanakuma, Jonan-ku Japan
  • 4 University of Palermo Department of Inorganic and Analytical Chemistry Viale delle Scienze, Parco d’Orleans 90128 Palermo Italy
  • 5 University of Bergen Department of Chemistry Allegaten 41 Bergen Norway
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Abstract  

Complexes of adenosine and related compounds (adenosine-5’-monophosphate, adenosine-5’-triphosphate and pyridoxal-5-phosphate) with Bu2SnO and/or BuSnCl2 were prepared in the solid state. The compositions of the complexes were determined by standard analytical methods. It was found that the complexes contain the organotin(IV) moiety and the ligand in a ratio of 1:1. The FT-IR spectra demonstrated that Bu2SnO reacts with the D-ribose moiety of the ligands, while Bu2SnCl2 is coordinated to the deprotonated phosphate group. The basic part of the ligands does not participate directly in complex formation. Comparison of the experimental Mössbauer Δ (quadrupole splitting) values with those calculated on the basis of the pqs concept revealed that the organotin(IV) moiety has Tbp and in some cases also Th geometry. The adenosine complex contains the organotin(IV) cation in two different surroundings (Tbp and Th). The local structures of the complexes were determined by means of EXAFS measurements. At the same time a number of organotin(IV) complexes containing different organo moieties of calf thymus DNA were also prepared. Similarly as above, EXAFS data were obtained for these compounds and analyzed by using multishell models up to 300 pm. These results are the first structural data (bond lengths) on complexes formed with organotin(IV)-DNA and related compounds.