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  • 1 PerkinElmer Life and Analytical Sciences, Inc. 549 Albany St. Boston Massachusetts 02118 USA
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Abstract  

The AChE inhibitor (−)-phenserine tartrate is a promising candidate as a treatment for Alzheimer’s disease and tritium labeling of it was required for biological testing. This was accomplished by a halogenation, catalytic tritium dehalogenation strategy resulting in a highly efficient incorporation of tritium. The position of tritium labeling was elucidated by a consideration of both proton and tritium NMR spectra.