Authors:
M. Javed Institute of Nuclear Medicine and Oncology (INMOL) Wahdat Road P. O. Box 10068 Lahore 54600 Pakistan

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I. Khan Institute of Nuclear Medicine and Oncology (INMOL) Wahdat Road P. O. Box 10068 Lahore 54600 Pakistan

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M. Naeem Institute of Nuclear Medicine and Oncology (INMOL) Wahdat Road P. O. Box 10068 Lahore 54600 Pakistan

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S. Asghar Institute of Nuclear Medicine and Oncology (INMOL) Wahdat Road P. O. Box 10068 Lahore 54600 Pakistan

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H. Naseer Institute of Nuclear Medicine and Oncology (INMOL) Wahdat Road P. O. Box 10068 Lahore 54600 Pakistan

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M. Iqbal University of Sargodha Department of Pharmacy Sargodha Pakistan

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J. Anwar University of the Punjab Institute of Chemistry Quaid-e-Azam Campus Lahore Pakistan

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Abstract  

A tetradentate set of N2O2 salicylaldehyde-amine-N-dione Schiff base was prepared by condensation with salicylaldehyde, ethylenediamine, 2,4-dione and reduction with NaBH4. The ligand system was characterized by 1H-NMR and FT-IR spectroscopy and HPLC. Radiolabeling studies of the 99mTc-complex were performed using stannous ions as the reducing agent. The purity of the complex was determined by ascending solvent system on paper chromatography and instant thin-layer chromatography (ITLC). The yield of the complex was >90%. Biodistribution of the 99mTc-complex of the precursor was studied in rabbits. A significant uptake and retention of injected activity was observed in the liver and cleared through the bladder. A faint activity was also observed in kidneys. These results indicate that the proposed system may be suitable for development of a liver/spleen imaging agent for future clinical applications.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)