Authors:
D. Cardoso Faculdade de Farmácia, UFMG Laboratório de Controle de Qualidade de Produtos Farmacêuticos e Cosméticos Minas Gerais Brasil

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R. Rodrigues Divisão de Produção de Imunobiológicos Funed Brasil

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V. Toledo Faculdade de Farmácia, UFMG Laboratório de Imunologia Clínica Minas Gerais Brasil

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T. Moraes-Santos Faculdade de Farmácia, UFMG Laboratório de Nutrição Experimental Minas Gerais Brasil

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V. Cardoso Faculdade de Farmácia, UFMG Laboratório de Radioisótopos Minas Gerais Brasil

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E. Nunan Faculdade de Farmácia, UFMG Laboratório de Controle de Qualidade de Produtos Farmacêuticos e Cosméticos Minas Gerais Brasil

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Abstract  

F(ab’)2 is the fragment involved in the immunotherapy for scorpion stings and it would be convenient to label it with 99mTc for organ distribution and pharmacokinetics studies. The aim of the present study was to label scorpion antivenom F(ab’)2 with 99mTc keeping its biological activity, integrity and stability. High labeling yield was obtained using stannous chloride and sodium borohydride. Stability, immunoreactivity and integrity of 99mTc-F(ab’)2 was preserved. It was not observed any difference between potencies of unlabeled and labeled antivenom. 99mTc-F(ab’)2 can be a useful tool for use in biodistribution and pharmacokinetics studies on the evaluation of the efficacy of the antivenom against scorpion envenomation.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)