Authors:
Guan-Quan Wang

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Ji Zhang Sichuan University Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education) Chengdu 610064 P.R. China

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Shun-Zhong Luo China Academy of Engineering Physics (CAEP) Institute of Nuclear Physics and Chemistry Mianyang 621900 P.R. China

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Na Wang Sichuan University Department of Chemistry, Key Laboratory of Green Chemistry and Technology (Ministry of Education) Chengdu 610064 P.R. China

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Hong-Yuan Wei China Academy of Engineering Physics (CAEP) Institute of Nuclear Physics and Chemistry Mianyang 621900 P.R. China

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Wen-Jin Wang China Academy of Engineering Physics (CAEP) Institute of Nuclear Physics and Chemistry Mianyang 621900 P.R. China

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Yu-Qing Yang China Academy of Engineering Physics (CAEP) Institute of Nuclear Physics and Chemistry Mianyang 621900 P.R. China

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Guo-Ping Liu China Academy of Engineering Physics (CAEP) Institute of Nuclear Physics and Chemistry Mianyang 621900 P.R. China

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Xiao-Qi Yu

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Abstract  

A new nitrido-188Re complex, 188ReN-NEMPTDD, was synthesized through a modified method in high yield. This complex was stable in vitro. The biodistribution in normal mice showed that this ReN complex accumulated in the liver and was eliminated quickly from almost all organs. VX2 carcinoma was grown in the livers of rabbits. Transcatheter arterial embolization (TAE) was performed using 188ReN-NEMPTDD/lipiodol solution. The SPECT images showed that the lipiodol solution could be concentrated in the tumor for about 12 hours. These results indicated that 188ReN-NEMPTDD/lipiodol could be a potential radiopharmaceutical for liver cancer.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)