Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 277: Issue 2
Radiochemical separation and quality assessment for the 68Zn target based 64Cu radioisotope production
Authors:
Le Van So Australian Nuclear Science and Technology Organisation Radiopharmaceutical Research Institute New Illawarra Road, Lucas Heights, P.M.B 1 Menai NSW 2234 Australia

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P. Pellegrini Australian Nuclear Science and Technology Organisation Radiopharmaceutical Research Institute New Illawarra Road, Lucas Heights, P.M.B 1 Menai NSW 2234 Australia

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A. Katsifis Australian Nuclear Science and Technology Organisation Radiopharmaceutical Research Institute New Illawarra Road, Lucas Heights, P.M.B 1 Menai NSW 2234 Australia

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J. Howse Australian Nuclear Science and Technology Organisation Radiopharmaceutical Research Institute New Illawarra Road, Lucas Heights, P.M.B 1 Menai NSW 2234 Australia

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I. Greguric Australian Nuclear Science and Technology Organisation Radiopharmaceutical Research Institute New Illawarra Road, Lucas Heights, P.M.B 1 Menai NSW 2234 Australia

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Pages:
451–466
Online Publication Date:
12 Mar 2008
Publication Date:
01 Aug 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-007-7143-x
Restricted access

Abstract  

The radiochemical separation of the different radionuclides (64Cu, 67Cu, 67Ga, 66Ga, 56Ni, 57Ni, 55Co, 56Co, 57Co, 65Zn, 196Au) induced in the Ni supported Cu substrate — 68Zn target system, which was bombarded with the 29.0 MeV proton beam, was performed by ion-exchange chromatography using successive isocratic and/or concentration gradient elution techniques. The overlapped gamma-ray spectrum analysis method was developed to assess the 67Ga and 67Cu content in the 64Cu product and even in the post-67Ga production 68Zn target solution without the support of radiochemical separation. This method was used for the assessment of 64+67Cu radioisotope separation from 67Ga, the quality control of 64Cu product and the determination of the 68Zn (p,2p)67Cu reaction yield. The improvement in the targetry and the optimization of proton beam energy for the 68Zn target based 64Cu and 67Ga production were proposed based on the stopping power and range of the incident proton and on the excitation functions, reaction yields and different radionuclides induced in the target system.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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