Authors:
F. Yurt Lambrecht Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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O. Yilmaz Dokuz Eylul University, School of Medicine Department of Animal Research Center Izmir Turkey

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P. Unak Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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B. Seyitoglu Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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K. Durkan Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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H. Baskan Dokuz Eylul University, School of Medicine Department of Microbiology Izmir Turkey

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Abstract  

Localizing and distinguishing the “infection” in body sites are very important and life saving processes. Scintigraphic detections may help to determine the sites of inflammation and infection. At this point, nuclear medical imaging may proceed one step further and be helpful to localize and distinguish the inflammation. The radiolabeled antibiotic 99mTc-Cefuroxime axetil was assessed as an infection imaging agent in a rat model. In this study, 99mTc-Cefuroxime axetil was examined in localizing the normal, sterile inflamed, and septic inflamed rat muscle tissues, and also in distinguishing each of them. The biodistribution data show that 99mTc labeled Cefuroxime axetil was retained in infectious areas. The retention was better in septic inflamed (S. aureus) area than sterile inflamed area. The clearance of the labeled antibiotic from other tissues is rapid on the contrary to its clearance from the septic area. Target/non-target ratio shows a good value of 2.5 at 4-hour post injection when the activity of the other organs is cleared by urinary excretion.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)