Imaging of bacterial infection with 99mTc-labeled HBD-1

F. Yurt Lambrecht; O. Yilmaz; P. Unak; B. Seyitoglu; K. Durkan; S. Yolcular; H. Baskin

doi:10.1007/s10967-007-7135-x

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Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 277: Issue 3

Imaging of bacterial infection with ^99mTc-labeled HBD-1

Authors:

F. Yurt Lambrecht

F. Yurt Lambrecht Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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O. Yilmaz

O. Yilmaz Dokuz Eylul University School of Medicine Department of Animal Research Center Izmir Turkey

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P. Unak

P. Unak Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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B. Seyitoglu

B. Seyitoglu Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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K. Durkan

K. Durkan Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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S. Yolcular

S. Yolcular Ege University Department of Nuclear Applications, Institute of Nuclear Sciences 35100 Bornova, Izmir Turkey

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H. Baskin

H. Baskin Dokuz Eylul University School of Medicine Department of Microbiology Izmir Turkey

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Pages:: 555–559

Online Publication Date:: 18 Apr 2008

Publication Date:: 01 Sep 2008

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-007-7135-x

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Abstract

The aim of this study was to evaluate ^99mTc labeled human β-defensin-1 (HBD-1) for discrimination between bacterial infection and sterile inflammation. For this purpose, HBD-1 was radiolabeled with ^99mTc and its in vivo distribution was evaluated in inflamed rats with Staphylococcus aureus (S. aureus) and sterile inflamed rats with turpentine oil. After injection into inflamed and sterile inflamed rats, ^99mTc-HBD-1 was rapidly removed from the circulation via the kidneys. Binding of ^99mTc-HBD-1 to inflamed muscle (T/NT = 20 at 120 min) was two times higher than binding to sterile inflamed muscle (T/NT = 10 at 120 min) of rats. It was demonstrated that ^99mTc-HBD-1 can be used to detect S. aureus inflammation in rats. However, the radiolabeled antimicrobial peptide showed only poor uptake in sterile inflammation with turpentine oil in rats. As a result, ^99mTc-HBD-1 can be useful for detection of bacterial inflammation.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)