Authors:
A. Jalilian Medicine and Industrial Research School (AMIRS) Nuclear Medicine Group, Agriculture Karaj P.O. Box 31485-498 Iran

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S. Shanehsazzadeh Isfahan University of Medical Sciences Department of Biomedical Physics and Engineering, School of Medicine Isfahan Iran

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M. Akhlaghi Medicine and Industrial Research School (AMIRS) Nuclear Medicine Group, Agriculture Karaj P.O. Box 31485-498 Iran

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J. Garousi Medicine and Industrial Research School (AMIRS) Nuclear Medicine Group, Agriculture Karaj P.O. Box 31485-498 Iran

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S. Rajabifar Medicine and Industrial Research School (AMIRS) Nuclear Medicine Group, Agriculture Karaj P.O. Box 31485-498 Iran

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M. Tavakoli Isfahan University of Medical Sciences Department of Biomedical Physics and Engineering, School of Medicine Isfahan Iran

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Abstract  

Gonadorelin was successively labeled with [67Ga]-gallium chloride after residulation with freshly prepared cyclic DTPA-dianhydride. The best results of the conjugation were obtained by the addition of 1 mg of a gonadorelin to a glass tube pre-coated with DTPA-dianhydride (0.33 mg) at 25 °C with continuous mild stirring for 1 hour. Radio thin layer chromatography showed an overall radiochemical purity of >90% at optimized conditions after labeling. HPLC showed a radiochemical purity more than 95% (specific activity = 400–450 GBq/M). The stability of the radioconjugate was tested in presence of human serum at 37 °C. Preliminary in vivo studies in normal rats were performed to determine the biodistribution of the conjugate up to 48 hours. The breast and ovaries uptakes were significantly high in first 15-minute post injection which is in agreement with the other reports regarding the presence of specific GnRH receptors. This tracer can be used in detection of GnRH receptor biodistribution in various diseases and malignancies.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)