Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 278: Issue 1
Synthesis and biodistribution of 99mTc(CO)3-DMSA-MIBI in mice
Authors:
Shuye Yang Beijing Normal University Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry Beijing 100875 P.R. China

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Xuebin Wang Beijing Normal University Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry Beijing 100875 P.R. China

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Haixun Guo Beijing Normal University Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry Beijing 100875 P.R. China

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Jian Liu Beijing Normal University Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry Beijing 100875 P.R. China

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Fenglong Wang Beijing Normal University Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry Beijing 100875 P.R. China

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Xianzhong Zhang Beijing Normal University Key Laboratory of Radiopharmaceutics, (Beijing Normal University), Ministry of Education, College of Chemistry Beijing 100875 P.R. China

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Pages:
165–171
Online Publication Date:
04 Jun 2008
Publication Date:
01 Oct 2008
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-007-7213-0
Restricted access

Abstract  

Mixed ligand fac-tricarbonyl complex of [99mTc(CO)3-DMSA-MIBI] has been prepared starting from the precursor [99mTc(OH2)3(CO)3]+. The complex can be obtained in good yield and purity in a two-step procedure by first attaching meso-2,3-dimercaptosuccinic acid (DMSA, HOOCCH(SH)CH(SH)COOH) with [99mTc(OH2)3(CO)3]+, followed by addition of MIBI [tetrakis-2-methoxyisobutylisonitrile (CH3OC(CH3)2CH2-N≡C) copper(I) tetrafluoroborate] solution. The complex was characterized by TLC and HPLC and was studied by means of octanol-water partition coefficient, electrophoresis, stability in vitro, and normal mice experiment. Biodistribution in mice demonstrated that the complex showed higher myocardial uptake after 0.5-hour p.i. The ratios of heart/liver (%ID/g) in the case of 99mTc(CO)3-DMSA-MIBI was higher (1.88) than that observed in case of 99mTc-MIBI1 (0.93) after 0.5-hour p.i. (P<0.05). Results showed that the complex may be developed to a novel myocardial perfusion-imaging agent.

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Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

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