Authors:
K. Eigner Henke Academy of Sciences of the Czech Republic (ASCR) Nuclear Physics Institute, v.v.i. (NPI) CZ-250 68 Řež Czech Republic

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M. Beran Academy of Sciences of the Czech Republic (ASCR) Nuclear Physics Institute, v.v.i. (NPI) CZ-250 68 Řež Czech Republic

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J. Srank Academy of Sciences of the Czech Republic (ASCR) Nuclear Physics Institute, v.v.i. (NPI) CZ-250 68 Řež Czech Republic

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F. Melichar Academy of Sciences of the Czech Republic (ASCR) Nuclear Physics Institute, v.v.i. (NPI) CZ-250 68 Řež Czech Republic

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Abstract  

The 90YCl3 radionuclide precursor (solution of 90Y3+ in diluted HCl) of high purity and high specific activity is already commercially produced and successfully used in nuclear medicine. At the Nuclear Physics Institute ASCR, the 90YCl3 radionuclide precursor is prepared using extraction 90Sr/90Y generator (technology of centrifuge extractors with di-2-ethylhexylphosphoric acid, D2EHPA).1 Its radionuclidic, radiochemical, and chemical purity were examined and specified. The procedure developed for labeling of DOTA-Tyr3-octreotide (DOTATOC) with carrier-free 86/90Y by Rösch2 at the Institute of Nuclear Chemistry of the University Mainz was optimized and modified in our Department of Radiopharmaceuticals at NPI ASCR as standard labeling test (SLT) for analytical purposes. The SLT as a method for 90YCl3 radionuclide precursor quality control determining its labeling efficiency using ITLC SG chromatography is described and proposed thereinafter. The labeling-efficiency of the tested batches of our product reached more than 95%.

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Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation
1968
Volumes
per Year
1
Issues
per Year
12
Founder Akadémiai Kiadó
Founder's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)