Synthesis and biodistribution of a novel 99mTc nitrido dithiocarbamate complex containing ether group as a potential myocardial and brain imaging agent

JunBo Zhang; Gang Luo; XueBin Wang

doi:10.1007/s10967-008-7383-4

Journal of Radioanalytical and Nuclear Chemistry

Volume/Issue:: Volume 279: Issue 3

Synthesis and biodistribution of a novel ^99mTc nitrido dithiocarbamate complex containing ether group as a potential myocardial and brain imaging agent

Authors:

JunBo Zhang

JunBo Zhang College of Chemistry, Beijing Normal University Key Laboratory of Radiopharmaceuticals, Ministry of Education Beijing 100875 P.R. China

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Gang Luo

Gang Luo College of Chemistry, Beijing Normal University Key Laboratory of Radiopharmaceuticals, Ministry of Education Beijing 100875 P.R. China

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, and

XueBin Wang

XueBin Wang College of Chemistry, Beijing Normal University Key Laboratory of Radiopharmaceuticals, Ministry of Education Beijing 100875 P.R. China

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Pages:: 783–785

Online Publication Date:: 31 Jan 2009

Publication Date:: 01 Mar 2009

Article Category:: Research Article

DOI:: https://doi.org/10.1007/s10967-008-7383-4

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Abstract

In the present study, a novel ^99mTc nitrido dithiocarbamate complex containing ether group, the bis(2-ethoxyethyl dithiocarbamato) nitrido ^99mTc complex ^99mTcN(EOEDTC)₂ has been synthesized by the reduction of ^99mTcO₄⁻ into [^99mTcN]²⁺ with stannous chloride in the presence of succinic dihydrazide and propylenediamine tetraacetic acid, followed by the addition of the corresponding dithiocarbamate ligand. The radiochemical purity of the complex was over 90% as measured by thin layer chromatography (TLC). In vitro studies showed that the complex possessed good stability. Its partition coefficient indicated that it was lipophilic complex. The electrophoresis results showed the complex was neutral. Biodistribution in mice showed that the complex accumulated in the heart and brain with high initial uptake, suggesting the complex may lead to a further development of the radiopharmaceutical as a heart and brain perfusion tracer.

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Journal of Radioanalytical and Nuclear Chemistry

Print ISSN:: 0236-5731

Online ISSN:: 1588-2780

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Journal of Radionalytical and Nuclear Chemistry
Language	English
Size	A4
Year of Foundation	1968
Volumes per Year	1
Issues per Year	12
Founder	Akadémiai Kiadó
Founder's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher	Akadémiai Kiadó Springer Nature Switzerland AG
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-5731 (Print)
ISSN	1588-2780 (Online)