Journal of Radioanalytical and Nuclear Chemistry
Volume/Issue:
Volume 279: Issue 3
Labeling of apigenin with 131I and bioactivity of 131I-apigenin in male and female rats
Authors:
B. Seyitoglu Ege University, Institute of Nuclear Science Department of Nuclear Applications Bornova 35100 Izmir Turkey

Search for other papers by B. Seyitoglu in
Current site
Google Scholar
PubMed Close
,
F. Yurt Lambrecht Ege University, Institute of Nuclear Science Department of Nuclear Applications Bornova 35100 Izmir Turkey

Search for other papers by F. Yurt Lambrecht in
Current site
Google Scholar
PubMed Close
, and
K. Durkan Ege University, Institute of Nuclear Science Department of Nuclear Applications Bornova 35100 Izmir Turkey

Search for other papers by K. Durkan in
Current site
Google Scholar
PubMed Close
Pages:
867–873
Online Publication Date:
07 Mar 2009
Publication Date:
01 Mar 2009
Article Category:
Research Article
DOI:
https://doi.org/10.1007/s10967-008-7401-6
Restricted access

Abstract  

Apigenin (4′,5,7-trihydroxyflavone), one of the most common flavonoids, has been shown to possess a variety of biological activities including tumor growth inhibition and chemopreventation. In the present study, apigenin was labeled with 131I using iodogen method and investigated of its bioactivity. Radiolabeling yield is 98±0.2%, as determined by radio thin layer chromatography (RTLC), electrophoresis and radio high performance liquid chromatography (RHPLC). Besides, structure analysis of synthesized cold iodoapigenin complex were assessed with LCMS/MS and 1H-NMR. Results of in vitro study indicated a high stability (3 hours) in human serum. Biodistrubition studies are performed in male and female albino Wistar rats. Biodistribution data related to the male rats showed significant uptake in the small intestine. The female rats biodistribution results indicated that the uptake of 131I-apigenin was high in the intestine and uterus.

  • Collapse
  • Expand
Cover Journal of Radioanalytical and Nuclear Chemistry
Journal of Radioanalytical and Nuclear Chemistry
Print ISSN:
0236-5731
Online ISSN:
1588-2780

To see the editorial board, please visit the website of Springer Nature.

Manuscript Submission: HERE

For subscription options, please visit the website of Springer Nature.

Journal of Radionalytical and Nuclear Chemistry
Language English
Size A4
Year of
Foundation		 1968
Volumes
per Year		 1
Issues
per Year		 12
Founder Akadémiai Kiadó
Founder's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Publisher Akadémiai Kiadó
Springer Nature Switzerland AG
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
CH-6330 Cham, Switzerland Gewerbestrasse 11.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5731 (Print)
ISSN 1588-2780 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Oct 2024 73 0 0
Nov 2024 17 0 0
Dec 2024 9 0 0
Jan 2025 36 0 0
Feb 2025 25 0 0
Mar 2025 13 0 0
Apr 2025 0 0 0